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Trends Biochem Sci. 2011 Sep;36(9):457-69. doi: 10.1016/j.tibs.2011.06.003. Epub 2011 Jul 20.

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling.

Author information

1
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. arun.shukla@receptor-biol.duke.edu

Abstract

β-Arrestins, originally discovered to desensitize activated seven transmembrane receptors (7TMRs; also known as G-protein-coupled receptors, GPCRs), are now well established mediators of receptor endocytosis, ubiquitylation and G protein-independent signaling. Recent global analyses of β-arrestin interactions and β-arrestin-dependent phosphorylation events have uncovered several previously unanticipated roles of β-arrestins in a range of cellular signaling events. These findings strongly suggest that the functional roles of β-arrestins are much broader than currently understood. Biophysical studies aimed at understanding multiple active conformations of the 7TMRs and the β-arrestins have begun to unravel the mechanistic basis for the diverse functional capabilities of β-arrestins in cellular signaling.

PMID:
21764321
PMCID:
PMC3168679
DOI:
10.1016/j.tibs.2011.06.003
[Indexed for MEDLINE]
Free PMC Article

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