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Dev Cell. 2011 Jul 19;21(1):134-44. doi: 10.1016/j.devcel.2011.06.006.

Notch ligand ubiquitylation: what is it good for?

Author information

1
Department of Biological Chemistry, David Geffen School of Medicine, University of California-Los Angeles, CA 90095, USA.

Abstract

In the first volume of Developmental Cell, it was reported that the classic Drosophila neurogenic gene neuralized encodes a ubiquitin ligase that monoubiquitylates the Notch ligand Delta, thus promoting Delta endocytosis. A requirement for ligand internalization by the signal-sending cell, although counterintuitive, remains to date a feature unique to Notch signaling. Ten years and many ubiquitin ligases later, we discuss sequels to these three papers with an eye toward reviewing the development of ideas for how ligand ubiquitylation and endocytosis propel Notch signaling.

PMID:
21763614
PMCID:
PMC3156059
DOI:
10.1016/j.devcel.2011.06.006
[Indexed for MEDLINE]
Free PMC Article

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