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Dev Cell. 2011 Jul 19;21(1):32-4. doi: 10.1016/j.devcel.2011.06.004.

Protein evolution in cell and tissue development: going beyond sequence and transcriptional analysis.

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1
Program in Cancer Biology, Stanford University, Stanford, CA 94305, USA.

Abstract

Studies of animal evolution often focus on sequence and transcriptional analysis, based on an assumption that the evolution of development is driven by changes in gene expression. We argue that biochemical and cell biological approaches are also required, because sequence-conserved proteins can have different biochemical, cellular, and developmental properties.

PMID:
21763606
PMCID:
PMC3145331
DOI:
10.1016/j.devcel.2011.06.004
[Indexed for MEDLINE]
Free PMC Article
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