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Biochim Biophys Acta. 2011 Oct;1808(10):2352-8. doi: 10.1016/j.bbamem.2011.06.020. Epub 2011 Jul 5.

Multifaceted action of Fuzeon as virus-cell membrane fusion inhibitor.

Author information

1
The Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel.

Abstract

The viral peptide fusion inhibitor Fuzeon (T-20/DP178/enfuvirtide) is an essential part of the drug combination that has significantly increased the quality of life and life span of many acquired immuno-deficiency syndrome (AIDS) patients. Its development as a drug preceded the elucidation of its precise inhibitory mechanism, as well as its molecular targets. The initial model was that Fuzeon inhibits human immunodeficiency virus (HIV) entry by targeting one site within the viral transmembrane envelope protein. Herein, we describe the emerging discoveries that extend this model towards a multifaceted mechanism for the drug in targeting HIV. This significantly advances the understanding of how viruses enter host cells and opens a new window of opportunity for designing future viral fusion inhibitors.

PMID:
21762676
DOI:
10.1016/j.bbamem.2011.06.020
[Indexed for MEDLINE]
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