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Virol J. 2011 Jul 15;8:352. doi: 10.1186/1743-422X-8-352.

Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication.

Author information

1
Institut de Parasitologie et Pathologie Tropicale, EA 4438, Université de Strasbourg, 3 rue Koeberlé, 67000 Strasbourg, France.

Abstract

The Human Phosphate-Binding protein (HPBP) is a serendipitously discovered lipoprotein that binds phosphate with high affinity. HPBP belongs to the DING protein family, involved in various biological processes like cell cycle regulation. We report that HPBP inhibits HIV-1 gene transcription and replication in T cell line, primary peripherical blood lymphocytes and primary macrophages. We show that HPBP is efficient in naïve and HIV-1 AZT-resistant strains. Our results revealed HPBP as a new and potent anti HIV molecule that inhibits transcription of the virus, which has not yet been targeted by HAART and therefore opens new strategies in the treatment of HIV infection.

PMID:
21762475
PMCID:
PMC3157455
DOI:
10.1186/1743-422X-8-352
[Indexed for MEDLINE]
Free PMC Article

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