Format

Send to

Choose Destination
See comment in PubMed Commons below
HPB (Oxford). 2011 Aug;13(8):579-85. doi: 10.1111/j.1477-2574.2011.00338.x. Epub 2011 Jun 24.

International multicentre prospective study on microwave ablation of liver tumours: preliminary results.

Author information

1
Department of Hepatobiliary and Pancreatic Surgery, Leicester Royal Infirmary, Leicester, UK. david.iannitti@carolinashealthcare.org

Abstract

BACKGROUND:

Microwave ablation (MWA) is increasingly utilized in the treatment of hepatic tumours. Promising single-centre reports have demonstrated its safety and efficacy, but this modality has not been studied in a prospective, multicentre study.

METHODS:

Eighteen international centres recorded operative and perioperative data for patients undergoing MWA for tumours of any origin in a voluntary Internet-based database. All patients underwent operative MWA using a 2.45-GHz generator with a 5-mm antenna.

RESULTS:

Of the 140 patients, 114 (81.4%) were treated with MWA alone and 26 (18.6%) were treated with MWA combined with resection. Multiple tumours were treated with MWA in 40.0% of patients. A total of 299 tumours were treated in these 140 patients. The median size of ablated lesions was 2.5 cm (range: 0.5-9.5 cm). Tumours were treated with a median of one application (range: 1-6 applications) for a median of 4 min (range: 0.5-30.0 min). A power setting of 100 W was used in 78.9% of cases. Major morbidity was 8.3% and in-hospital mortality was 1.9%.

CONCLUSIONS:

These multi-institution data demonstrate rapid ablation time and low morbidity and mortality rates in patients undergoing operative MWA with a high rate of multiple ablations and concomitant hepatic resection. Longterm follow-up will be required to determine the efficacy of MWA relative to other forms of ablative therapy.

PMID:
21762302
PMCID:
PMC3163281
DOI:
10.1111/j.1477-2574.2011.00338.x
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center