Critical care guidelines on the endovascular management of cerebral vasospasm

Neurocrit Care. 2011 Sep;15(2):336-41. doi: 10.1007/s12028-011-9600-1.

Abstract

Cerebral vasospasm and delayed cerebral ischemia account for significant morbidity and mortality after aneurysmal subarachnoid hemorrhage. While most patients are managed with triple-H therapy, endovascular treatments have been used when triple-H treatment cannot be used or is ineffective. An electronic literature search was conducted to identify English language articles published through October 2010 that addressed endovascular management of vasospasm. A total of 49 articles were identified, addressing endovascular treatment timing, intra-arterial treatments, and balloon angioplasty. Most of the available studies investigated intra-arterial papaverine or balloon angioplasty. Both have generally been shown to successfully treat vasospasm and improve neurological condition, with no clear benefit from one treatment compared with another. There are reports of complications with both therapies including vessel rupture during angioplasty, intracranial hypertension, and possible neurotoxicity associated with papaverine. Limited data are available evaluating nicardipine or verapamil, with positive benefits reported with nicardipine and inconsistent benefits with verapamil.

Publication types

  • Consensus Development Conference
  • Practice Guideline

MeSH terms

  • Acute Disease
  • Angioplasty, Balloon*
  • Brain Ischemia / drug therapy
  • Brain Ischemia / etiology
  • Calcium Channel Blockers / therapeutic use*
  • Critical Care / methods*
  • Humans
  • Subarachnoid Hemorrhage / complications
  • Subarachnoid Hemorrhage / therapy*
  • Vasodilator Agents / therapeutic use
  • Vasospasm, Intracranial / drug therapy*
  • Vasospasm, Intracranial / etiology

Substances

  • Calcium Channel Blockers
  • Vasodilator Agents