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Appl Microbiol Biotechnol. 2011 Sep;91(5):1287-96. doi: 10.1007/s00253-011-3457-2. Epub 2011 Jul 15.

Bio-based production of the platform chemical 1,5-diaminopentane.

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Institute of Biochemical Engineering, Technische Universit├Ąt Braunschweig, Gaussstrasse 17, 38106 Braunschweig, Germany.


In the rising era of bio-economy, the five carbon compound 1,5-diaminopentane receives increasing interest as platform chemical, especially as innovative building block for bio-based polymers. The vital interest in bio-based supply of 1,5-diaminopentane has strongly stimulated research on the development of engineered producer strains. Based on the state-of-art knowledge on the pathways and reactions linked to microbial 1,5-diaminopentane metabolism, the review covers novel systems metabolic engineering approaches towards hyper-producing cell factories of Corynebacterium glutamicum or Escherichia coli. This is integrated into the whole value chain from renewable feedstocks via 1,5-diaminopentane to innovative biopolymers involving bioprocess engineering considerations for economic supply.

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