Format

Send to

Choose Destination
Nat Rev Immunol. 2011 Jul 15;11(8):532-43. doi: 10.1038/nri3014.

Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms.

Author information

1
Institute for Immunology and Informatics and Department of Cell and Molecular Biology, University of Rhode Island, Providence, Rhode Island 02903, USA. arothman.uri@gmail.com

Abstract

Dengue is a mosquito-borne viral disease of expanding geographical range and incidence. The existence of four viral serotypes and the association of prior dengue virus infection with an increased risk for more severe disease have presented significant obstacles to vaccine development. An increased understanding of the adaptive immune response to natural dengue virus infection and candidate dengue vaccines has helped to define the specific antibody and T cell responses that are associated with either protective or pathological immunity during dengue infection. Further characterization of immunological correlates of disease outcome and the validation of these findings in vaccine trials will be invaluable for developing effective dengue vaccines.

PMID:
21760609
DOI:
10.1038/nri3014
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center