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Mult Scler. 2011 Nov;17(11):1295-300. doi: 10.1177/1352458511411063. Epub 2011 Jul 14.

High frequency of co-infection by Epstein-Barr virus types 1 and 2 in patients with multiple sclerosis.

Author information

1
Department of Pathology, Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain. asanton.hrc@salud.madrid.org

Abstract

BACKGROUND:

The existence of Epstein-Barr virus (EBV) strains specifically associated with multiple sclerosis (MS) is a matter of controversy. Little is also known about the prevalence of EBV types 1 and 2 in MS patients and the presence of co-infections by both strains.

OBJECTIVE:

To make EBV strain type assignment and compare the frequencies of types 1, 2 and co-infections by both in MS patients and healthy controls.

METHODS:

Blood samples from 75 consecutive MS patients and 186 controls were collected. EBV was simultaneously detected and typed using a polymerase chain reaction (PCR) which amplified a strain-specific sequence in the EBV nuclear antigen 2.

RESULTS:

EBV was detected in 70 out of 75 patients (93.3%) and in 123 of 186 controls (66.1%). Among positive cases, type 1 was found in 6 patients (8.6%) and 40 controls (32.5%), type 2 in 1 patient (1.4%) and 37 controls (30.1%), and dual-infections by both EBV types were detected in 63 patients (90%) and 46 controls (37.4%). Logistic regression models showed that MS was significantly associated with the presence of EBV (p < 0.001) and also with dual type infections (p < 0.001).

CONCLUSION:

This study provides molecular evidence associating co-infection of type 1 and 2 EBV with MS.

PMID:
21757537
DOI:
10.1177/1352458511411063
[Indexed for MEDLINE]
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