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Mult Scler. 2012 Feb;18(2):229-31. doi: 10.1177/1352458511414965. Epub 2011 Jul 14.

Modelling the distribution of cortical lesions in multiple sclerosis.

Author information

1
Biostatistics Unit, Department of Health Sciences, University of Genoa, Italy. mariapia.sormani@unige.it

Abstract

Recent studies have shown the relevance of the cerebral grey matter involvement in multiple sclerosis (MS). Cortical lesions (CLs), detected by specific MRI sequences, are likely to become a new research outcome in MS studies. The aim of this study was to infer the optimal statistical model describing the distribution of CLs in patients with relapsing-remitting (RR)MS. The negative binomial model gave the best fit to the observed distribution of CLs in a group of 44 RRMS patients with one MRI scan of the brain. This observation has important implications for the statistical analysis of CLs in MS studies.

PMID:
21757533
DOI:
10.1177/1352458511414965
[Indexed for MEDLINE]

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