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FEBS Lett. 1990 Nov 26;275(1-2):44-8.

The structure of protein phosphatase 2A is as highly conserved as that of protein phosphatase 1.

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Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.


cDNA coding for protein phosphatase 2A (PP2A) has been isolated from Drosophila head and eye imaginal disc libraries. Drosophila PP2A mRNA is expressed throughout development, but is most abundant in the early embryo. The cDNA hybridises to a single site on the left arm of the second chromosome at position 28D2-4. The deduced amino acid sequence (309 residues) of Drosophila PP2A shows 94% identity with either rabbit PP2A alpha or PP2A beta, indicating that PP2A may be the most conserved of all known enzymes.

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