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Mutat Res. 2011 Jul-Oct;728(1-2):1-11. doi: 10.1016/j.mrrev.2011.06.003. Epub 2011 Jul 2.

Exploring the processes of DNA repair and homologous integration in Neurospora.

Author information

1
Department of Regulation Biology, Saitama University, Urawa, Japan. hinoue@mail.saitama-u.ac.jp

Abstract

This review offers a personal perspective on historical developments related to our current understanding of DNA repair, recombination, and homologous integration in Neurospora crassa. Previous reviews have summarized and analyzed the characteristics of Neurospora DNA repair mutants. The early history is reviewed again here as a prelude to a discussion of the molecular cloning, annotation, gene disruption and reverse genetics of Neurospora DNA repair genes. The classical studies and molecular analysis are then linked in a perspective on new directions in research on mutagen-sensitive mutants.

PMID:
21757027
DOI:
10.1016/j.mrrev.2011.06.003
[Indexed for MEDLINE]

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