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J Dermatolog Treat. 2012 Oct;23(5):385-92. doi: 10.3109/09546634.2011.568470. Epub 2011 Jul 14.

Curcuma aeruginosa, a novel botanically derived 5α-reductase inhibitor in the treatment of male-pattern baldness: a multicenter, randomized, double-blind, placebo-controlled study.

Author information

1
Cosmetic and Natural Product Research Center, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand.

Abstract

BACKGROUND:

Several botanically derived agents are available for the treatment of male-pattern baldness.

OBJECTIVE:

The aim of this study was to evaluate the efficacy of 5% hexane extract of Curcuma aeruginosa, a botanically derived inhibitor of 5α-reductase and 5% minoxidil in the treatment of androgenetic alopecia.

METHODS:

Eighty-seven men with androgenetic alopecia (AGA) were randomized to receive 5% Curcuma aeruginosa, 5% minoxidil, combination formulation (5% hexane extract of Curcuma aeruginosa + 5% minoxidil) or placebo, twice daily for 6 months. Efficacy was assessed by target area hair count, global photographic review as well as patients' subjective assessments of hair regrowth and hair shedding.

RESULTS:

There were statistically significant improvements in global photographic review (p < 0.001), subjects' overall assessments of hair regrowth (p = 0.008), and hair shedding (p = 0.004) when the combination formulation was compared with placebo. Similarly, treatment with 5% minoxidil and 5% C. aeruginosa extract also led to some degrees of hair regrowth. There were no serious adverse events during and after the study.

CONCLUSION:

In men with hair loss in the vertex area of the scalp, the combination of 5% hexane extract of C. aeruginosa and 5% minoxidil slowed hair loss and increased hair growth.

PMID:
21756154
DOI:
10.3109/09546634.2011.568470
[Indexed for MEDLINE]

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