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Clin Lab. 2011;57(5-6):297-303.

Is osmol gap an effective screen in accurate prediction of toxic volatiles?

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  • 1Department of Pathology and Lab Medicine, College of Medicine, University of Saskatchewan, 103 Hospital Drive, Saskatoon, Canada.


A review of the literature was done to determine the number of studies published on the osmol gap. We wanted to examine whether these studies were able to establish a consensus on the formula to be used, the appropriate reference interval to be used and finally the performance of the osmol gap in its ability as a screening test for toxic volatile substance. Our study was disappointing since no published literature exists to allow the clinical laboratory to use the osmol gap based on evidenced based studies.

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