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Mov Disord. 2011 Nov;26(13):2422-7. doi: 10.1002/mds.23863. Epub 2011 Jul 13.

Long-term outcome of 32 patients with chorea and systemic lupus erythematosus or antiphospholipid antibodies.

Author information

1
Service de Neurologie, AP-HP, Hôpital Lariboisière, Paris, France. peggyreiner@yahoo.fr

Abstract

OBJECTIVE:

The aim of this work was to describe chorea during systemic lupus erythematosus or antiphospholipid antibodies and its long-term outcome.

METHODS:

We retrospectively analyzed clinical features, laboratory findings, imaging characteristics, and outcome in a series of 32 patients.

RESULTS:

Most patients were women (28 of 32), and mean age at onset of chorea was 20.6 (9-62) years. Chorea was inaugural for 28 patients. Improvement was observed with various treatments. During follow-up (12.2 ± 11.3 years), severe manifestations of systemic lupus erythematosus were rare. Antiphospholipid antibodies were repeatedly positive for 90% of the patients. Twelve patients developed arterial thrombosis. Prophylactic treatment with antithrombotic therapy might reduce the risk of further thrombosis (8% versus 57%; P = 0.01). Cardiac valvulopathy occurred in 22 patients during follow-up. Chorea relapsed in 8 cases.

CONCLUSIONS:

Chorea had a good outcome in itself. This long-term follow-up shows, for the first time, that these patients have substantial risk for further arterial thrombosis.

PMID:
21755538
DOI:
10.1002/mds.23863
[Indexed for MEDLINE]

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