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J Biophotonics. 2011 Aug;4(7-8):471-81. doi: 10.1002/jbio.201100048. Epub 2011 Jul 13.

Future and advances in endoscopy.

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1
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.

Abstract

The future of endoscopy will be dictated by rapid technological advances in the development of light sources, optical fibers, and miniature scanners that will allow for images to be collected in multiple spectral regimes, with greater tissue penetration, and in three dimensions. These engineering breakthroughs will be integrated with novel molecular probes that are highly specific for unique proteins to target diseased tissues. Applications include early cancer detection by imaging molecular changes that occur before gross morphological abnormalities, personalized medicine by visualizing molecular targets specific to individual patients, and image guided therapy by localizing tumor margins and monitoring for recurrence.

PMID:
21751414
PMCID:
PMC3517128
DOI:
10.1002/jbio.201100048
[Indexed for MEDLINE]
Free PMC Article
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