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Proteomics. 2011 Aug;11(16):3424-9. doi: 10.1002/pmic.201000212.

Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.

Author information

1
Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.

Abstract

Pseudomonas aeruginosa, an opportunistic human bacterial pathogen, constitutively secretes outer membrane vesicles (OMVs) into the extracellular milieu. Although recent progress has revealed that OMVs are essential for pathogenesis of P. aeruginosa, their proteins have not been comprehensively analyzed so far. In this study, we identified 338 vesicular proteins with high confidence by five separate LC-MS/MS analyses. This global proteome profile provides a basis for future studies to elucidate the pathological functions of OMVs from P. aeruginosa.

PMID:
21751344
DOI:
10.1002/pmic.201000212
[Indexed for MEDLINE]

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