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Chem Commun (Camb). 2011 Aug 28;47(32):9134-6. doi: 10.1039/c1cc13052h. Epub 2011 Jul 13.

The effect of heteroatom substitution of sulfur for selenium in glucosidase inhibitors on intestinal α-glucosidase activities.

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1
Department of Chemistry, Simon Fraser University, Burnaby, British Colombia, Canada V5A 1S6.

Abstract

The synthesis of selenium analogues of de-O-sulfonated ponkoranol, a naturally occurring sulfonium-ion glucosidase inhibitor isolated from Salacia reticulata, and their evaluation as glucosidase inhibitors against two recombinant intestinal enzymes maltase glucoamylase (MGAM) and sucrase isomaltase (SI) are described.

PMID:
21750824
DOI:
10.1039/c1cc13052h
[Indexed for MEDLINE]
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