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Emerg Infect Dis. 2011 Jun;17(6):976-82. doi: 10.3201/eid/1706.101483.

Binary toxin and death after Clostridium difficile infection.

Author information

1
European Programme for Intervention Epidemiology Training, Stockholm, Sweden. cci@ssi.dk

Abstract

We compared 30-day case-fatality rates for patients infected with Clostridium difficile possessing genes for toxins A and B without binary toxin (n = 212) with rates for patients infected with C. difficile possessing genes for A, B, and binary toxin. The latter group comprised patients infected with strains of PCR ribotype 027 (CD027, n = 193) or non-027 (CD non-027, n = 72). Patients with binary toxin had higher case-fatality rates than patients without binary toxin, in univariate analysis (relative risk [RR] 1.8, 95% confidence interval [CI] 1.2-2.7) and multivariate analysis after adjustment for age, sex, and geographic region (RR 1.6, 95% CI 1.0-2.4). Similar case-fatality rates (27.8%, 28.0%) were observed for patients infected with CD027 or CD non-027. Binary toxin either is a marker for more virulent C. difficile strains or contributes directly to strain virulence. Efforts to control C. difficile infection should target all virulent strains irrespective of PCR ribotype.

PMID:
21749757
PMCID:
PMC3358205
DOI:
10.3201/eid/1706.101483
[Indexed for MEDLINE]
Free PMC Article

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