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J Assist Reprod Genet. 2011 Sep;28(9):815-20. doi: 10.1007/s10815-011-9604-y. Epub 2011 Jul 12.

Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems.

Author information

1
IVF Department, Zekai Tahir Burak Women Education and Research Hospital, Devlet Mah. Subay Loj. Hızırreis Apt. No: 19/11, Yenisehir, Ankara, Turkey. drozlemgun@yahoo.com

Abstract

PURPOSE:

We aimed to analyse the in vitro fertilization-embryo transfer (IVF-ET) outcomes of the patients with sleep disturbances who were administered melatonin.

METHODS:

A total of 60 patients with sleep disturbances were divided into two groups. The study group (group A, n=30) had underwent the IVF-ET with melatonin administration and the control group (group B, n=30) without melatonin. Sleeping status after melatonin administration and the IVF outcomes were compared between the two groups.

RESULTS:

Sleeping status change was not significant (p>0.05). The mean number of the retrieved oocytes, the mean MII oocyte counts, the G1 embryo ratio were significantly higher in the melatonin administered group (group A) than that the non-administered group (group B); p=0.0001; p=0.0001; p<0.05 respectively.

CONCLUSION:

IVF patients with sleep disorders may benefit from melatonin administration in improving the oocyte and the embryo quality, but the sleeping problem itself may not be fixed.

PMID:
21748445
PMCID:
PMC3169684
DOI:
10.1007/s10815-011-9604-y
[Indexed for MEDLINE]
Free PMC Article

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