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Biol Blood Marrow Transplant. 2011 Dec;17(12):1739-46. doi: 10.1016/j.bbmt.2011.07.003. Epub 2011 Jul 13.

Can G-CSF cause leukemia in hematopoietic stem cell donors?

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1
The Ohio State University, Columbus, Ohio, USA.

Abstract

A large majority of allogeneic hematopoietic stem cell donations are achieved using granulocyte-colony stimulating factor (G-CSF). G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances. Although clinical data to date have failed to identify any increased incidence of MDS/AML in G-CSF mobilized donors, the quality of these data are insufficient to exclude a long-term risk. Physicians should explain the potential risk to donors, and where appropriate, offer donors the option of marrow donation.

PMID:
21745453
DOI:
10.1016/j.bbmt.2011.07.003
[Indexed for MEDLINE]
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