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Int J STD AIDS. 2011 Aug;22(8):478-80. doi: 10.1258/ijsa.2011.010490. Epub 2011 Jul 8.

Is azithromycin adequate treatment for asymptomatic rectal chlamydia?

Author information

1
The Kirby Institute, University of NSW, Sydney, Australia. fdrummond@kirby.unsw.edu.au

Abstract

Rectal chlamydia is a common sexually transmissible infection (STI) in men who have sex with men (MSM) that is predominantly asymptomatic. The recommended treatment of azithromycin 1 g as a single oral dose has not been subject to randomized trials and so its efficacy is unknown. We conducted a retrospective case-note review of all MSM diagnosed at the Sydney Sexual Health Centre with asymptomatic rectal chlamydia in 2009. We identified 116 MSM who received azithromycin; 85 (73%) attended for the recommended re-test at varying times (median 78 days, range 21-372 days). Of the men who returned, 11 (13%) had a persistently positive result; we reviewed behavioural data to classify these men as probable re-infections (6/11) or possible treatment failures (5/11), suggesting an efficacy of 94%. Until a randomized controlled trial (RCT) is conducted, patients with rectal chlamydia should be encouraged to attend for a re-test at 6-12 weeks.

PMID:
21742812
DOI:
10.1258/ijsa.2011.010490
[Indexed for MEDLINE]

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