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Trends Cardiovasc Med. 2010 Jul;20(5):143-8. doi: 10.1016/j.tcm.2010.12.002.

Omentin: a novel link between inflammation, diabesity, and cardiovascular disease.

Author information

1
Endocrinology and Metabolism Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, CV4 7AL Coventry, UK. b.k.tan.1@warwick.ac.uk

Abstract

Obesity has reached pandemic proportions and is associated with serious cardiometabolic sequelae including insulin resistance, diabetes, dyslipidemia, hypertension, and cardiovascular disease, where adipose tissue-secreted cytokines, that is, adipokines, have been implicated in these processes. Omentin is a novel adipokine preferentially produced by visceral adipose tissue with insulin-sensitizing effects, where circulating levels are decreased in insulin-resistant states, for example, obesity and diabetes. With respect to vascular biology, omentin causes vasodilatation of blood vessels and attenuates C-reactive protein-induced angiogenesis potentially via the nuclear factor B signaling pathway, a potent proinflammatory signaling pathway. Thus, omentin may have beneficial effects on the metabolic syndrome and could potentially be used as a biologic marker and/or pharmacologic agent in this respect.

PMID:
21742269
DOI:
10.1016/j.tcm.2010.12.002
[Indexed for MEDLINE]

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