A canine model (group A = 7, B = 7, C = 6) was developed for the study of post-resuscitative disease following untreated ventricular fibrillation with ventilatory arrest (2.5, 5.0, and 7.5 min, respectively). Non-invasive circulatory support (pneumatic vest/binder), with accompanying ventilatory support, was administered for 20.0, 20.0 and 15.0 min, respectively, followed by defibrillation, recovery and elective euthanasia. Sodium bicarbonate and epinephrine were administered during support and early recovery. Group A received the least amount of sodium bicarbonate during cardiopulmonary support and had the highest mean arterial pressure during early recovery. Group B received the most epinephrine during cardiopulmonary support and in total. There were no significant differences in total energy applied during defibrillation. In group A, there was a positive correlation between the total energy applied during defibrillation and the amount of epinephrine administered during early recovery. In group B, there was a positive correlation between the amount of epinephrine administered during cardiopulmonary support and the total energy applied during defibrillation and a negative correlation between the total energy applied and the mean arterial pressure during early recovery. The neurological quality of survival in this model will permit the protracted study of organ dysfunction(s) following prolonged cardiopulmonary arrest and support.