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Cancer Cell. 2011 Jul 12;20(1):3-5. doi: 10.1016/j.ccr.2011.06.021.

BCL6: a novel target for therapy of Ph+ B cell acute lymphoblastic leukemia.

Author information

  • 1Molecular Oncology Research Institute, Division of Hematology/Oncology, Tufts Medical Center, Boston, MA 02111, USA. rvanetten@tuftsmedicalcenter.org

Abstract

BCL6 is a zinc-finger transcriptional repressor known for its oncogenic role in B cell lymphoma. In a recent issue of Nature, Duy et al. describe a novel role for BCL6 at the center of a transcriptional network in Ph(+) acute lymphoblastic leukemia cells that modulates their leukemogenicity and response to kinase inhibitors.

PMID:
21741592
DOI:
10.1016/j.ccr.2011.06.021
[PubMed]
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