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J Mol Neurosci. 2011 Nov;45(3):690-5. doi: 10.1007/s12031-011-9576-5. Epub 2011 Jul 8.

Immunotherapy for tauopathies.

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1
Department of Physiology and Neuroscience, New York University, School of Medicine, 550 First Avenue, New York, NY 10016, USA.

Abstract

Pathological tau protein is found in Alzheimer's disease and related tauopathies. The protein is hyperphosphorylated and/or mutated which leads to aggregation and neurotoxicity. Because cognitive functions correlate well with the degree of tau pathology, clearing these aggregates is a promising therapeutic approach. Studies pioneered by our laboratory and confirmed by others have shown that both active and passive immunizations targeting disease-related tau epitopes successfully reduce tau aggregates in vivo and slow or prevent behavioral impairments in mouse models of tauopathy. Here, we summarize recent advances in this new field.

PMID:
21739165
PMCID:
PMC3265133
DOI:
10.1007/s12031-011-9576-5
[Indexed for MEDLINE]
Free PMC Article
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