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PLoS One. 2011;6(6):e21565. doi: 10.1371/journal.pone.0021565. Epub 2011 Jun 27.

Resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against Aβ and Aβ-metal complexes toxicity.

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1
Centro Nazionale delle Ricerche, Istituto Tecnologie Biomediche, Metalloproteins Unit, Department of Biology, University of Padova, Padova, Italy.

Abstract

It has been recently suggested that resveratrol can be effective in slowing down Alzheimer's disease (AD) development. As reported in many biochemical studies, resveratrol seems to exert its neuro-protective role through inhibition of β-amyloid aggregation (Aβ), by scavenging oxidants and exerting anti-inflammatory activities. In this paper, we demonstrate that resveratrol is cytoprotective in human neuroblastoma cells exposed to Aβ and or to Aβ-metal complex. Our findings suggest that resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties.

PMID:
21738712
PMCID:
PMC3124535
DOI:
10.1371/journal.pone.0021565
[Indexed for MEDLINE]
Free PMC Article
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