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Ann Dermatol. 2011 Feb;23(1):39-43. doi: 10.5021/ad.2011.23.1.39. Epub 2011 Feb 28.

Seroepidemiologic survey of varicella-zoster virus in korean adults using glycoprotein enzyme immuno assay and fluorescent antibody to membrane antigen test.

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  • 1Department of Microbiology, College of Medicine, Yeungnam University, Daegu, Korea.

Abstract

BACKGROUND:

Herpes zoster (HZ) occurs mainly in the elderly and Korea is rapidly becoming an aging society. Therefore, it is important to know the immune status against varicella-zoster virus (VZV) in Korean adults to prevent the disease.

OBJECTIVE:

The aim of this study was to survey the immune status of Korean adults over 40 years of age against VZV.

METHODS:

Antibody titer was measured using a VaccZyme™ VZV glycoprotein enzyme immunoassay (gpEIA) (Binding Site, UK). Fluorescent antibody to membrane antigen (FAMA) test was performed to measure the seropositive rate.

RESULTS:

HZ incidence in the 214 adults enrolled in this study was 10.3%. The gpEIA geometric mean titer (GMT) was 490 mIU/ml and 90.2% of the subjects had a protective level of gpEIA antibody titer against varicella. The average gpEIA GMT of adults who previously had HZ was 1,122 mIU/ml, which was higher than the average gpEIA GMT of 457 mIU/ml in adults who had not had HZ. The FAMA positive rate was 98.6%.

CONCLUSION:

Most (90.2%) Korean adults ≥40-years-of-age have a protective level of gpEIA antibody against varicella and 98.6% were FAMA seropositive. The GMT of gpEIA antibody was significantly increased with age, and was higher in adults with a history of HZ.

KEYWORDS:

Glycoprotein enzyme immunoassay; Herpes-Zoster; Seroprevalence

PMID:
21738361
PMCID:
PMC3119997
DOI:
10.5021/ad.2011.23.1.39
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