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Bioorg Med Chem. 2011 Nov 15;19(22):6608-14. doi: 10.1016/j.bmc.2011.06.004. Epub 2011 Jun 16.

Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum.

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Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.


Palmerolides D-G are new bioactive macrolides isolated from the Antarctic tunicate Synoicum adareanum and are related to the melanoma-selective cytotoxin palmerolide A. Most of these palmerolides are potent V-ATPase inhibitors and have sub-micromolar activity against melanoma. Though palmerolide A remains the most potent of this series of natural products against mammalian V-ATPase, recent data suggests that palmerolide D is the most potent against melanoma. A comparison of the bioactivity data obtained for these natural product palmerolides has provided insight into the substructures necessary to retain V-ATPase inhibition and cytotoxic activity.

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