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Bioorg Med Chem. 2011 Aug 1;19(15):4574-88. doi: 10.1016/j.bmc.2011.06.014. Epub 2011 Jun 16.

Discovery of selective indole-based prostaglandin D₂ receptor antagonist.

Author information

1
Minase Research Institute, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai, Shimamoto, Mishima, Osaka 618-8585, Japan. iwahashi@ono.co.jp

Abstract

A series of N-benzoyl-2-methylindole-3-acetic acids were synthesized and biologically evaluated as prostaglandin (PG) D₂ receptor antagonists. Some of the selected compounds significantly inhibited OVA-induced vascular permeability in guinea pig conjunctiva after oral dosing. Structure-activity relationship study is presented.

PMID:
21737285
DOI:
10.1016/j.bmc.2011.06.014
[Indexed for MEDLINE]

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