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Radiother Oncol. 2011 Oct;101(1):223-5. doi: 10.1016/j.radonc.2011.06.018. Epub 2011 Jul 5.

Dependence of cell survival on instantaneous dose rate of a linear accelerator.

Author information

1
Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark. bsin@oncology.dk

Abstract

BACKGROUND AND PURPOSE:

With the development of flattening filter-free linear accelerators for radiotherapy, the instantaneous dose rate has increased by approximately a factor 4. This leads to the question of whether there may be a radiobiological consequence. The present study investigates the radiobiological effect of this high instantaneous dose rate on two cell lines.

MATERIALS AND METHODS:

A Varian Trilogy TX linear accelerator was used to directly compare the effect of three different dose rates (5.01, 9.99 and 29.91 Gy/min, with instantaneous dose rates in the pulse of 56.5, 112.8 and 338 Gy/s) on clonogenic survival. V79 and FaDu(DD) cells were irradiated with doses in a range from 1 to 10 Gy in order to obtain dose response curves.

RESULTS:

For both cell lines, there is not observed any effect of the instantaneous dose rate on cell survival.

PMID:
21737168
DOI:
10.1016/j.radonc.2011.06.018
[Indexed for MEDLINE]

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