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Neuroreport. 2011 Aug 24;22(12):575-80. doi: 10.1097/WNR.0b013e328348e6aa.

Histone H3 phosphoacetylation is critical for heroin-induced place preference.

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Pharmacology Research Center and State Key Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai, China.


We investigated the role of histone H3 phosphoacetylation in the nucleus accumbens (NAc) in heroin-conditioned place preference paradigm. Heroin could dose-dependently increase histone H3 phosphoacetylation specifically in the NAc and could enhance heroin place preference. Injection of trichostatin A into the NAc significantly augmented heroin-induced histone H3 phosphoacetylation and enhanced heroin place preference. Conversely, injection of MK-801 into the NAc attenuated histone H3 phosphoacetylation and reduced heroin place preference. These data suggest that histone H3 phosphoacetylation in the NAc may play a critical role in heroin addiction.

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