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RNA Biol. 2011 Sep-Oct;8(5):719-27. doi: 10.4161/rna.8.5.16226. Epub 2011 Jul 11.

HDV-like self-cleaving ribozymes.

Author information

1
Department of Molecular Biology, University of California, Irvine, CA, USA.

Abstract

HDV ribozymes catalyze their own scission from the transcript during rolling circle replication of the hepatitis delta virus. In vitro selection of self-cleaving ribozymes from a human genomic library revealed an HDV-like ribozyme in the second intron of the human CPEB3 gene and recent results suggest that this RNA affects episodic memory performance. Bioinformatic searches based on the secondary structure of the HDV/CPEB3 fold yielded numerous functional ribozymes in a wide variety of organisms. Genomic mapping of these RNAs suggested several biological roles, one of which is the 5' processing of non-LTR retrotransposons. The family of HDV-like ribozymes thus continues to grow in numbers and biological importance.

PMID:
21734469
PMCID:
PMC3256349
DOI:
10.4161/rna.8.5.16226
[Indexed for MEDLINE]
Free PMC Article

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