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RNA Biol. 2011 Sep-Oct;8(5):802-5. doi: 10.4161/rna.8.5.16038. Epub 2011 Jul 19.

An RNA G-quadruplex in the 3' UTR of the proto-oncogene PIM1 represses translation.

Author information

1
Institut für Molekulare Biowissenschaften, Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt/Main, Germany.

Abstract

We have identified a conserved G-quadruplex forming sequence in the 3' untranslated region (UTR) of the proto-oncogene PIM1. Circular dichroism and thermal denaturation studies revealed that the PIM1 mRNA guanine-rich sequence forms a highly stable intramolecular G-quadruplex structure. Reporter gene assay demonstrated that the PIM1 RNA G-quadruplex represses translation. It is the first experimental evidence of an RNA G-quadruplex structure located in the 3' UTR that may act as posttranscriptional regulator.

PMID:
21734463
DOI:
10.4161/rna.8.5.16038
[Indexed for MEDLINE]

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