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Cell Cycle. 2011 Aug 1;10(15):2461-70. Epub 2011 Aug 1.

BRCT domains: easy as one, two, three.

Author information

1
Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.

Abstract

BRCA1 C-terminal (BRCT) domains are integral signaling modules in the DNA damage response (DDR). Aside from their established roles as phospho-peptide binding modules, BRCT domains have been implicated in phosphorylation-independent protein interactions, DNA binding and poly(ADP-ribose) (PAR) binding. These numerous functions can be attributed to the diversity in BRCT domain structure and architecture, where domains can exist as isolated single domains or assemble into higher order homo- or hetero- domain complexes. In this review, we incorporate recent structural and biochemical studies to demonstrate how structural features allow single and tandem BRCT domains to attain a high degree of functional diversity.

PMID:
21734457
PMCID:
PMC3180187
DOI:
10.4161/cc.10.15.16312
[Indexed for MEDLINE]
Free PMC Article
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