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Sci Transl Med. 2011 Jul 6;3(90):90ps27. doi: 10.1126/scitranslmed.3001880.

Development of newborn and infant vaccines.

Author information

1
Children's Hospital Boston, Boston, MA 02115, USA. ofer.levy@childrens.harvard.edu

Abstract

Vaccines for early-life immunization are a crucial biomedical intervention to reduce global morbidity and mortality, yet their developmental path has been largely ad hoc, empiric, and inconsistent. Immune responses of human newborns and infants are distinct and cannot be predicted from those of human adults or animal models. Therefore, understanding and modeling age-specific human immune responses will be vital to the rational design and development of safe and effective vaccines for newborns and infants.

PMID:
21734174
PMCID:
PMC4108897
DOI:
10.1126/scitranslmed.3001880
[Indexed for MEDLINE]
Free PMC Article

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