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Biofouling. 2011 Aug;27(7):701-10. doi: 10.1080/08927014.2011.597051.

Surface acoustic waves increase the susceptibility of Pseudomonas aeruginosa biofilms to antibiotic treatment.

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The Institute for Nanotechnology and Advanced Materials, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, 52900, Israel.


Bacterial urinary tract infections resulting from prolonged patient catheterization have become a major health problem. One of the major issues is bacterial resistance to antibiotic treatments due to biofilm formation inside the catheters, thus enhancing the search for alternative treatments. In the present study, a device containing a piezo element capable of transmitting low-frequency surface acoustic waves (SAW) onto the indwelling catheter was used. The SAW were able to eradicate biofilm-residing bacteria by >85% when applied simultaneously with an antibiotic in three clinically relevant species, viz. Escherichia coli, Staphylococcus epidermidis and Pseudomonas aeruginosa. Moreover, transcriptome analysis revealed that SAW can alter the transcription pattern of P. aeruginosa, suggesting that this signal can be specifically sensed by the bacterium.

[Indexed for MEDLINE]

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