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J Oral Maxillofac Pathol. 2010 Jul;14(2):77-9. doi: 10.4103/0973-029X.72507.

Keratoameloblastoma of the mandible.

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Department of Oral Pathology, University of Ibadan, Nigeria.


Keratoameloblastoma is a very rare ameloblastoma variant defined by extensive squamous metaplasia and keratinization. There are 13 previously reported cases in the literature, with a male predilection of 3:1. A 38-year-old male presented with a painless mandibular swelling which had been progressively increasing in size for 18 months. The incisional biopsy was misdiagnosed as basaloid squamous carcinoma. Owing to financial constraints, the patient had mandibular resection a decade after first noticing the growth, during which the clinical course was essentially benign, thus casting doubt on the initial diagnosis. The final histological diagnosis for both the incisional and resection biopsy specimens was keratoameloblastoma.


Keratoameloblastoma; ameloblastoma; keratinization; mandible; misdiagnosis; prognosis

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