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Br J Cancer. 2011 Jul 26;105(3):438-40. doi: 10.1038/bjc.2011.253. Epub 2011 Jul 5.

Second to fourth digit ratio (2D:4D) and prostate cancer risk in the Melbourne Collaborative Cohort Study.

Author information

1
Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Victoria, Australia. David.Muller@cancervic.org.au

Abstract

BACKGROUND:

The ratio of the lengths of index and ring fingers (2D:4D) is a marker of prenatal exposure to sex hormones, with low 2D:4D being indicative of high prenatal androgen action. Recent studies have reported a strong association between 2D:4D and risk of prostate cancer.

METHODS:

A total of 6258 men participating in the Melbourne Collaborative Cohort Study had 2D:4D assessed. Of these men, we identified 686 incident prostate cancer cases. Hazard ratios (HRs) and confidence intervals (CIs) were estimated for a standard deviation increase in 2D:4D.

RESULTS:

No association was observed between 2D:4D and prostate cancer risk overall (HRs 1.00; 95% CIs, 0.92-1.08 for right, 0.93-1.08 for left). We observed a weak inverse association between 2D:4D and risk of prostate cancer for age <60, however 95% CIs included unity for all observed ages.

CONCLUSION:

Our results are not consistent with an association between 2D:4D and overall prostate cancer risk, but we cannot exclude a weak inverse association between 2D:4D and early onset prostate cancer risk.

PMID:
21730975
PMCID:
PMC3172910
DOI:
10.1038/bjc.2011.253
[Indexed for MEDLINE]
Free PMC Article
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