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Leukemia. 2011 Nov;25(11):1674-86. doi: 10.1038/leu.2011.167. Epub 2011 Jul 5.

Bone marrow stem cell mobilization in stroke: a 'bonehead' may be good after all!

Author information

1
Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA. cborlong@health.usf.edu

Abstract

Mobilizing bone cells to the head, astutely referred to as 'bonehead' therapeutic approach, represents a major discipline of regenerative medicine. The last decade has witnessed mounting evidence supporting the capacity of bone marrow (BM)-derived cells to mobilize from BM to peripheral blood (PB), eventually finding their way to the injured brain. This homing action is exemplified in BM stem cell mobilization following ischemic brain injury. Here, I review accumulating laboratory studies implicating the role of therapeutic mobilization of transplanted BM stem cells for brain plasticity and remodeling in stroke.

PMID:
21727900
PMCID:
PMC3291108
DOI:
10.1038/leu.2011.167
[Indexed for MEDLINE]
Free PMC Article
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