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Cell Stem Cell. 2011 Jul 8;9(1):11-5. doi: 10.1016/j.stem.2011.06.008.

The MSC: an injury drugstore.

Author information

1
Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, OH 44106-7080, USA. arnold.caplan@case.edu

Abstract

Now that mesenchymal stem cells (MSCs) have been shown to be perivascular in vivo, the existing traditional view that focuses on the multipotent differentiation capacity of these cells should be expanded to include their equally interesting role as cellular modulators that brings them into a broader therapeutic scenario. We discuss existing evidence that leads us to propose that during local injury, MSCs are released from their perivascular location, become activated, and establish a regenerative microenvironment by secreting bioactive molecules and regulating the local immune response. These trophic and immunomodulatory activities suggest that MSCs may serve as site-regulated "drugstores" in vivo.

PMID:
21726829
PMCID:
PMC3144500
DOI:
10.1016/j.stem.2011.06.008
[Indexed for MEDLINE]
Free PMC Article

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