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J Bacteriol. 2011 Sep;193(17):4531-3. doi: 10.1128/JB.05393-11. Epub 2011 Jul 1.

Escherichia coli nucleoside diphosphate kinase mutants depend on translesion DNA synthesis to prevent mutagenesis.

Author information

1
Graduate Program in Molecular Microbiology, Sackler School of Graduate Biomedical Science, Tufts University School of Medicine, Boston, MA 02111, USA.

Abstract

Escherichia coli nucleoside diphosphate (NDP) kinase mutants have an increased frequency of spontaneous mutation, possibly due to uracil misincorporation into DNA. Here we show that NDP kinase mutants are dependent on translesion DNA synthesis, often a mutagenic form of DNA synthesis, to prevent mutagenesis.

PMID:
21725024
PMCID:
PMC3165513
DOI:
10.1128/JB.05393-11
[Indexed for MEDLINE]
Free PMC Article

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