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J Biol Chem. 2011 Aug 26;286(34):29922-31. doi: 10.1074/jbc.M111.233858. Epub 2011 Jul 1.

Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds.

Author information

1
Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.

Abstract

A class of anti-virulence compounds, the salicylidene acylhydrazides, has been widely reported to block the function of the type three secretion system of several Gram-negative pathogens by a previously unknown mechanism. In this work we provide the first identification of bacterial proteins that are targeted by this group of compounds. We provide evidence that their mode of action is likely to result from a synergistic effect arising from a perturbation of the function of several conserved proteins. We also examine the contribution of selected target proteins to the pathogenicity of Yersinia pseudotuberculosis and to expression of virulence genes in Escherichia coli O157.

PMID:
21724850
PMCID:
PMC3191033
DOI:
10.1074/jbc.M111.233858
[Indexed for MEDLINE]
Free PMC Article

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