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Curr Opin Microbiol. 2011 Aug;14(4):400-5. doi: 10.1016/j.mib.2011.06.002. Epub 2011 Jul 1.

Iron homeostasis--Achilles' heel of Aspergillus fumigatus?

Author information

1
Division of Molecular Biology/Biocenter, Innsbruck Medical University, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria.

Abstract

The opportunistic fungal pathogen Aspergillus fumigatus adapts to iron limitation by upregulation of iron uptake mechanisms including siderophore biosynthesis and downregulation of iron-consuming pathways to spare iron. These metabolic changes depend mainly on the transcription factor HapX. Consistent with the crucial role of iron in pathophysiology, genetic inactivation of either HapX or the siderophore system attenuates virulence of A. fumigatus in a murine model of aspergillosis. The differences in iron handling between mammals and fungi might serve to improve therapy and diagnosis of fungal infections.

PMID:
21724450
PMCID:
PMC3162135
DOI:
10.1016/j.mib.2011.06.002
[Indexed for MEDLINE]
Free PMC Article

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