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Cell Immunol. 2011;271(1):16-28. doi: 10.1016/j.cellimm.2011.05.016. Epub 2011 Jun 14.

B-cell activating factor (BAFF) promotes CpG ODN-induced B cell activation and proliferation.

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Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatchewan, Canada.


It is controversial whether naïve B cells are directly activated in response to TLR9 ligand, CpG ODN. Although bovine blood-derived CD21(+) B cells express TLR9 and proliferate in response to CpG in mixed-cell populations, purified bovine B cells do not proliferate significantly in response to CpG ODN, even when the B cell receptor is engaged. When co-cultured with CD14(+) myeloid cells and/or B-cell activating factor (BAFF), a cytokine produced by activated myeloid cells, there was a significant increase in CpG-specific B cell proliferation, and the number of large B cells in general or positive for CD25, all of which are markers for B cell activation. These data suggest that activated myeloid cells and BAFF prime B cells for significant CpG-specific activation. Understanding the signals required to mediate efficient CpG-induced, antigen-independent and T-cell independent activation of B cells has implications for polyclonal B cell activation and the development of autoimmune diseases.

[Indexed for MEDLINE]

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