Format

Send to

Choose Destination
Cell Metab. 2011 Jul 6;14(1):9-19. doi: 10.1016/j.cmet.2011.06.003.

Hormonal regulation of hepatic glucose production in health and disease.

Author information

1
Merck Research Laboratories, Rahway, NJ 07065, USA.

Abstract

We review mechanisms that regulate production of glucose by the liver, focusing on areas of budding consensus, and endeavoring to provide a candid assessment of lingering controversies. We also attempt to reconcile data from tracer studies in humans and large animals with the growing compilation of mouse knockouts that display changes in glucose production. A clinical hallmark of diabetes, excessive glucose production remains key to its treatment. Hence, we attempt to integrate emerging pathways into the broader goal to rejuvenate the staid antidiabetic pharmacopeia.

PMID:
21723500
PMCID:
PMC3131084
DOI:
10.1016/j.cmet.2011.06.003
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center