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Cell Metab. 2011 Jul 6;14(1):5-6. doi: 10.1016/j.cmet.2011.06.004.

Islets have a lot of nerve! Or do they?

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VA Puget Sound Health Care System and the University of Washington, Seattle, WA 98108, USA.


The autonomic nervous system influences insulin and glucagon secretion. In this issue, Rodriguez-Diaz et al. (2011) show that mouse and human islets differ in their innervation patterns, yet the effect of neural activation on islet hormone secretion is similar. Key questions raised by this species difference have potential relevance to diabetic therapeutics.

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