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J Neuroimmunol. 1990 Nov;30(1):23-9.

Effect of food-restriction stress on immune response in mice.

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Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Japan.


Daily 23-h food deprivation for 1-5 days induced gastric ulcers and atrophic changes of the spleen and thymus, accompanied by a rise in plasma cortisol and catecholamine levels in mice. It also modulated several immune cell functions in the spleen including a drop in the B cell population but no change in the mitogen response of the B cells, an increase in T cell population but no change in the L3T4/Lyt2 ratio and an early increase in natural killer activity and O2- production by macrophages. These effects are thought to correlate to the increase in stress-associated humoral factors and this may partly result from stress induced by food restriction.

[Indexed for MEDLINE]

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