The can and can't dos of p53 RNA

Biochimie. 2011 Nov;93(11):1962-5. doi: 10.1016/j.biochi.2011.06.010. Epub 2011 Jun 23.

Abstract

The p53 protein, like any other protein, cannot be made in the cell without RNA. And even once made, the p53 protein will be more rapidly degraded without the p53 RNA. Furthermore, the p53 RNA helps deciding which p53 isoform should be produced and under which cell conditions. Mutant p53 mRNA codes for an unstable and inactive protein. These matters are discussed in this article as well as the recent reports on p53 RNA mutations, interacting-proteins, 3' processing and 5'-3' loop.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Mice
  • Mutant Proteins / genetics
  • Mutant Proteins / metabolism
  • Polymorphism, Single Nucleotide
  • Protein Binding / genetics
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Protein Stability
  • Proteolysis
  • Proto-Oncogene Proteins c-mdm2 / genetics
  • Proto-Oncogene Proteins c-mdm2 / metabolism*
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism
  • Tumor Suppressor Protein p53 / genetics*
  • Tumor Suppressor Protein p53 / metabolism*
  • Untranslated Regions / genetics*

Substances

  • Mutant Proteins
  • Protein Isoforms
  • RNA, Messenger
  • Tumor Suppressor Protein p53
  • Untranslated Regions
  • Proto-Oncogene Proteins c-mdm2